GPCRs

Process of research about G protein-coupled receptor;

G蛋白偶联受体研究进展

A Rapid, Nongenomic Mechanism of Androgens in Prostate Cancer Cells Via a G Protein-Coupled Receptor;

G蛋白偶联受体介导雄激素对前列腺癌细胞快速作用的非基因组机制

G Protein-coupled receptors are a group of drug targets with important physiological functions and of pathological significance.

G蛋白偶联受体具有重要的生理功能和病理意义,已成为一类重要的药物靶点。

Metabotropic glutamate receptors 1/5 (mGluR 1/5) is an important member of family of C G protein coupled receptor (GPCRs).

代谢型谷氨酸受体1/5(mGluR1/5)是G蛋白偶联受体家族C的重要成员之一,该受体及其介导的下游信号在调节神经系统的正常生理功能起着非常重要作用,并与相关神经系统退行性疾病密切相关。

G protein coupled receptors are seven-transmembrance integrated membrane proteins,which mediate numerous cellular signal transduction events triggered by a variety of molecules and compounds such as hormones,neurotransmitters,light,odours and taste.

G蛋白偶联受体(GPCR)是具有7次跨膜螺旋的细胞整合膜蛋白,它们广泛地参与感光、气味、神经传递以及细胞增殖、分化、迁移等各类生理活动的调控,是现代药物研发的重要靶点。

Modulatory role of lipid rafts on GPCR signaling

脂筏在G蛋白偶联受体信号转导中的调控作用

G protein-coupled receptors(GPCR)belong to a superfamily of receptors and have numerous members.

G蛋白偶联受体(GPCR)是受体中家族成员最多的一大类,其活性涉及体内绝大部分的生理功能,在药物研发过程中是主要的药物作用靶标。

Gang Pei It has been well established that the sympathetic nervous system (SNS) can regulate the immune system primarily by (2-adrenergic receptor ((2AR), an important G protein-coupled receptor (GPCR) in the immune system, and that nuclear factor-kappaB (NF-(B) plays a central role in innate and adaptive immunity.

过去几十年的研究已经证明交感神经系统能够调控免疫系统的功能,广泛分布于免疫系统的一种G蛋白偶联受体(GPCRs)--(2肾上腺素受体((2AR),是这种调控作用的主要介导者。

The G-protein coupled receptors account for the majority of membrane receptors.

G蛋白偶联受体(GPCR)是目前已发现受体中种类最多的一类。

G-protein coupled receptors (GPCRs) constitute the largest family of transmembrane proteins.

G蛋白偶联受体(G-protein Coupled Receptors,GPCRs)是人体内最大的膜受体蛋白家族,对GPCRs及其功能的研究不仅有助于了解细胞信号转导的机制、阐明疾病的致病机理,而且还可为药物的研发提供新的思路,因而具有重要的理论意义和应用价值。

exigua PBANR characterized structurally members of G-protein coupled receptor family as predicted by amino acids sequence analysis software.

2、应用软件分析氨基酸序列表明甜菜夜蛾的PBANR为G蛋白偶联受体家族成员之一,由7个跨膜结构域,1个胞外N端结构域,1个胞内C端结构域,3个胞外和3个胞内环状结构域组成。

G protein-coupled receptors (GPCRs) which constitute the largest superfamily of receptors in human genome, regulate a variety of physiological functions and pathological processes.

G蛋白偶联受体是体内最大的受体超家族,它们参与调节生物体内多种生理功能与病理过程。

Extra-cellular signals are directly or indirectly transmitted into cells by G protein-coupled receptors(GPCRs).

很多胞外信号直接或间接通过G蛋白偶联受体向胞内传输。

G-protein coupled receptors(GPCRs)belong to the biggest subfamily of transmembran receptors.

G蛋白偶联受体(GPCR s)是最大的细胞膜受体家族,具有七螺旋跨膜肽段结构。

The paper also reviewed the applications of this technique in signal transduction of G protein-coupled receptors and new drug discovery.

本文系统阐述了BRET的原理和方法,综述了BRET技术的最新进展,以及该技术在G蛋白偶联受体(GPCRs)信号转导及药物发现中的应用。

Recent studies have shown that several orphan G protein-coupled receptors(GPCRs) as membrane receptor for FFAs exist in cell membrane.

本文就游离脂肪酸G蛋白偶联受体的结构、分布、配体选择性、下游信号通路,及其介导FFA生理功能的最新研究进展进行简要综述。

G Protein-coupled Receptors Regulate Amyloid-β Production;

G蛋白偶联受体调节β淀粉样蛋白的产生

Effect of G Protein βγ Subunitson Phosphorylation of G-protein Coupled Receptors

G蛋白βγ亚基影响G蛋白偶联受体磷酸化的作用研究

Cloning, Analyzing and Ligand Screening of hGPCRc as a Member of Human Orphan G Protein-coupled Receptor;

孤儿G蛋白偶联受体hGPCRc克隆、分析及配基筛选

Development of Drug Screening Models Targeted to G Protein-Coupled Receptors Based on Scintillation Proximity Assay;

针对G蛋白偶联受体的SPA药物筛选技术研究

Functional Analysis of Two Putative G-protein Coupled Receptors in Magnaporthe Grisea;

稻瘟病菌两个假定G蛋白偶联受体的功能分析

Study of the Specificity of GPCR Regulation of GIRK Channels;

G蛋白偶联受体调节GIRK通道的特异性研究

Isolation Characterization and Expression of cDNA Clones Encoding a G Protein-coupled Receptor Kinase of the Ascidian Ciona Intestinalis;

海鞘G蛋白偶联受体激酶cDNA的克隆定性与表达

Prediction of Functional Sites and SNPs in G Protein-coupled Receptors;

G蛋白偶联受体功能位点与功能性SNPs的预测

The Fine Research of the Activation Mechanism of GPCR Family C

C族G蛋白偶联受体激活机制的精细研究

Modulatory role of lipid rafts on GPCR signaling

脂筏在G蛋白偶联受体信号转导中的调控作用

G protein coupled receptorsare important receptor proteins in cell surface.

G蛋白偶联受体是细胞表面一类重要的受体蛋白。

The Repertoire of G-Protein-Coupled Receptors in Xenopus Tropicalis

热带爪蟾G蛋白偶联受体的系统发生及比较基因组学分析

The expressions of G protein-coupled receptor 30 and phosphorylated AKT in endometrial adenocarcinoma

G蛋白偶联受体30和磷酸化AKT在子宫内膜腺癌中表达及意义

Signal Pathway and Physiological Functions of Free Fatty Acids Mediated by G Protein-coupled Receptors

G蛋白偶联受体介导游离脂肪酸的信号通路及生理功能

A Rapid, Nongenomic Mechanism of Androgens in Prostate Cancer Cells Via a G Protein-Coupled Receptor;

G蛋白偶联受体介导雄激素对前列腺癌细胞快速作用的非基因组机制

Role of MAPK pathway in GPR40 mediated NIT-1 cells lipoapoptosis

MAPK通路在G蛋白偶联受体40介导的小鼠胰岛NIT-1细胞脂性凋亡中的作用

Role of GPR40 mediates the effects of FFAs on lipoapoptosis in mouse β-cell line NIT-1

G蛋白偶联受体40在游离脂肪酸影响小鼠胰岛NIT-1细胞脂性凋亡中的作用

G-Protein-Coupled Receptor 120-GPR120:Molecular Modeling Studies

G-蛋白偶联受体GPR120分子模建研究