dna repair

Advances in the research of DNA repair and cervical cancer;

DNA修复与宫颈癌的研究新进展

Polymorphisms of DNA repair genes are predictive factors for the tumor response and prognosis to platinum chemotherapy;

DNA修复基因单核苷酸多态性预测铂类药物敏感性和预后

Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury;

DNA修复基因XRCC1多态性与辐射损伤易感性的关系

hMSH2 deficiency of DNA repair enzyme and cell genetic stability;

DNA修复酶hMSH2缺陷与细胞遗传不稳定性

Structures and functions of DNA repair enzymes;

DNA修复酶的结构和功能

To date, at least 12 FA genes have been found deleted or mutated in FA cells, and 10 FA gene products form a core complex involved in FA/BRCA2 DNA repair pathway?FA pathway.

目前已经发现至少12种FA基因的缺失或突变能够引起FA表型的出现,其中10种相应的编码蛋白形成FA复合物共同参与FA/BRCA2 DNA损伤修复途径—FA途径。

Previous studies show that p33 ING1b is involved in growth inhibition, apoptosis, chromatin remodeling, DNA repair, tumor suppression and cellular senescence, but its biochemical function and involvement in cellular senescence is still not fully uncharacterized.

p33ING1b是一个较晚发现的肿瘤抑制基因ING1的主要表达形式,但是它在细胞衰老过程中的作用特别是对衰老细胞DNA损伤修复的影响还没有被阐明。

Methylation of DNA mismatch repair gene MLH1 and MSH2 in acquired multidrug-resistance of human small cell lung cells H446;

DNA错配修复基因甲基化在H446细胞获得性耐药中的作用

Advances of researches on the composition and function of DNA mismatch repair system;

DNA错配修复系统组成和功能的研究进展

Frequent Ki-ras Mutation in MSI-H Colorectal Cancer Deficient in DNA Mismatch Repair Genes;

DNA错配修复基因缺陷的MSI-H大肠癌频发Ki-ras基因点突变

Objective To explore the correlation between genetic polymorphisms of XRCC1,XPD,XRCC3and DNA repair capacity induced by benzene.

方法以确诊并已脱离苯作业的80名慢性苯中毒患者作为病例组,以同期接苯的62名苯作业工人为对照组,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术,检测XRCC1 C26304T(Arg194Trp)、G27466A(Arg280His)、G28152A(Arg399Gln)、G36189A(Gln632Gln)和XPD C22541A(Arg156Arg)、C23591T(Asp312Asn)、A35931C(Lys751Gln)以及XRCC3 C18067T(Thr241Met)位点的多态性,采用细胞阻滞微核试验和碱性彗星试验分别从细胞水平和分子水平检测DNA修复能力。

[Objective] To detect the DNA repair capacity of cancer patients after the exposure to radiomimetic compounds.

方法采集20名不同类型肿瘤病人和20名非肿瘤病人的淋巴细胞,用浓度为20μg/ml的博来霉素(Bleomycin)作用30 min后,再经15 min修复,采用彗星试验检测Bleomycin暴露前后DNA损伤程度来评价DNA修复能力。

OBJECTIVE To approach The Correlation of DNA repair capacity and cisplatin resistance in Advanced Non-Small-Cell Lung Cancer, and to provide theoretical supports for predicting the efficacy of cisplatin-based chemotherapy on Non-small-cell lung cancer patients.

目的：探讨晚期非小细胞肺癌患者(NSCLC)机体DNA修复能力(DNA repair capacity，DRC)与顺铂为基础方案化疗后产生耐药之间的关系，为临床预测晚期非小细胞肺癌患者对顺铂方案化疗是否有效提供理论依据。

The functions of BRCA1 and BRCA2 in DNA damage repair and transcriptional regulation;

BRCA1和BRCA2与DNA损伤修复及转录调控

Cultured A-T cells lack radiation-induced cell cycle checkpoints and express cellular defects that correlate with the clinical phenotype, such as the defect of DNA damage repair capacity and a high rate of apoptosis.

人拓扑异构酶Ⅲ(human topoisomeraseⅢ，hTOP3)基因具有介导DNA损伤修复的功能。

Studies on irradiation-resistant bacteria and their mechanism of DNA damage repair have been received considerable attention from the scientific community.

极端耐辐射微生物和耐辐射微生物DNA损伤修复机制研究对于环境保护和生物修复、人类健康以及生物技术创新等有着重大的理论和应用意义,是目前全球研究的热点。

The difference in DNA repair capacity among persons depends on the polymorphisms of DNA repair genes.

机体间存在DNA修复能力(DNA repair capacity,DRC)的差异主要是取决于DNA修复基因的多态性。

Relationship between polymorphisms of DNA repair genes and esophageal cancer susceptibility;

目的研究DNA修复基因-着色性干皮病基因A(XPA)、着色性干皮病基因D(XPD)、X线修复交叉互补基因1(XRCC1)和X线修复交叉互补基因3(XRCC3)多态性与食管癌易感性的关系。