acetate-mevalonate pathway

Through spectrophotometric analyses on cell extracts of ZWL73 induced with 3-HBA,it was indicated that glutathione(GSH)-dependent gentisate pathway is involved in the 3-HBA catabolism in ZWL73 and the catabolism of this pathway must be induced with 3-.

一株4-氯硝基苯(4-CNB)的完全降解菌Pseudomonas putidaZWL73能利用3-羟基苯甲酸(3-HBA)为惟一碳源和能源生长,而且ZWL73在对3-HBA降解的过程中,有中间产物龙胆酸生成;酶学分析的分光光度法证实,ZWL73通过GSH依赖型的龙胆酸途径代谢3-HBA,并且该途径需经3-HBA或龙胆酸诱导。

Through spectrophotometric analyses on cell extracts of ZWL73 induced with 3-HBA, it was indicated that glutathione(GSH)-dependent gentisate pathway is involved in the 3-HBA catabolism in ZWL73 and the catabolism of this pathway needs to be induced with 3-HBA .

一株4-氯硝基苯(4-CNB) 的完全降解菌Pseudomonas putida ZWL73能利用3-羟基苯甲酸(3-HBA) 为唯一碳源和能源进行生长,而且ZWL73 在对3-HBA降解的过程中,有中间产物龙胆酸的生成;酶学分析的分光光度法证实,ZWL73通过依赖于还原型谷胱甘肽(GSH)的龙胆酸途径代谢3-HBA,并且该途径的酶需要经过3-HBA 或龙胆酸的诱导。

And it can yet synthesize drug perpenoid “mevalomic lactone” that has largish applied cost.

由于用该试剂比较容易进行Reformatsky反应,可合成强效镇痛药“依那朵林”的中间体4-苯并呋喃乙酸,以及具有强心作用的“强心甾”等医药,也可合成很有应用价值的药物萜类化合物“甲瓦龙酸内酯”等。